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A trichological food supplement in tablet form, from Melannurca Campana IGP®, which, in association with copper, selenium and biotin, is able to counter hair loss and dulling, promoting hair growth and thickening. Scientific studies have shown that the polyphenol complex contained in AnnurMets hair Forte is able to intensively activate the metabolism of keratinocytes and melanocytes in the hair bulb, promoting hair growth and pigmentation, thus, conveying hair body, volume and colour. 

AnnurMets hair Forte, in its strengthened form, is the result of numerous clinical tests, conducted in collaboration with the Department of Pharmacy of the University of Naples ‘Federico II’, which made it possible to measure the optimal dosage of the active ingredients to achieve surprising results in just three months’ intake.

Composition
Bulking agent: microcrystalline cellulose; Melannurca (Malus pumila Miller cultivar Annurca) fruit i.e. procyanidin “AnnurtriComplex®”; Anti-caking agents: magnesium salts of fatty acids, silicon dioxide, talc; Red film coating: (glazing agents: shellac, hydroxy-propyl methylcellulose, talc, polyethylene glycol; silicon dioxide, colouring agents: calcium carbonate, iron oxides and hydroxides); Selenium methionine, Zinc acetate, Copper gluconate, Biotin.

Doses and usage information
Recommended 2 tablets per day between meals.
GLUTEN- AND LACTOSE-FREE
SUITABLE FOR VEGANS

A no-rinse lotion from on AnnurtriComplex®, an extract from Melannurca Campana IGP®, capable of enhancing the life cycle of the hair, facilitating microcirculation and regulating sebaceous hypersecretion. Thanks to its green and eco-friendly formula, it exerts a soothing action on irritated areas of the scalp. In combination with AnnurMets hair tablets, regrowth effects are maximised.

Composition
Water, Ethoxydiglycol, Malus pumila Miller cultivar Annurca fruit extract, Panthenol, Maltodextrin, Potassium sorbate, Sodium benzoate, Zinc gluconate, Biotin, Silica, Citric acid.

AnnurMets hair revitalising anti-hair loss shampoo with extract from Melannurca Campana IGP ‘AnnurtriComplex’ is particularly suitable for combating hair loss, thanks to the unique properties of Melannurca, in combination with amino acids, vitamins and ginseng extract. Its exceptional moisturising and soothing properties are conveyed by the exclusive use of plant-derived surfactants and an ecofriendly conditioner. Contains no sulphates, parabens or other hazardous chemicals.
AnnurMets Hair Shampoo, a valuable ally and ideal complement to the food supplement AnnurMets Hair Tablets, gives back vitality to weakened hair and prevents hair loss. Clinical studies, conducted in collaboration with the Department of Pharmacy of the University of Naples ‘Federico II’, have shown that the procyanidin complex ‘AnnurtriComplex®’, found in AnnurMets hair Shampoo, increases keratin production and boosts the vitality of the hair bulb, by strengthening the hair at the roots and helping to prevent hair loss.

Composition
Water, Cocamidopropyl betaine, Ammonium lauryl sulfate, Malus Pumila Miller Cultivar Annurca Fruit Extract, Lauryl glucoside, Sodium lauryl glucose carboxylate, Decyl glucoside, Xanthan gum, Glyceryl oleate, Coco-glucoside, Maltodextrin, Dicaprylyl ether, Potassium sorbate, Quaternium-87, Sodium benzoate, Panax ginseng extract, Lactic acid, Silica, Arginine, Acetyl tyrosine, Arctium majus extract, Hydrolyzed soy protein, PEG-12 dimethicone, Polyquaternium-11, Calcium pantothenate, Zinc gluconate, Niacinamide, Ornithine HCl, Citrulline, Glucosamine HCl, Biotin, Aroma.

AnnurMets hair restorative shampoo with Melannurca Campana IGP ‘AnnurtriComplex’ extract has been formulated to give back vitality, softness and shine to dry, brittle hair damaged by sun, chlorine, permanent colouring, chemical straightening, and the use of straighteners and hairdryers. In addition to Melannurca extract, the shampoo is rich in keratin and pantrofine, amino acids known for their effective nourishing, protective and moisturising action on the hair. With vegetable-derived surfactants and an ecofriendly conditioner. It contains no sulphates, parabens or other hazardous chemicals.
AnnurMets hair Shampoo, a valuable ally and ideal complement to the food supplement AnnurMets hair tablets, nourishes and restructures the hair right from the root. Clinical studies, conducted in collaboration with the Department of Pharmacy of the University of Naples ‘Federico II’, have shown that the procyanidin complex ‘AnnurtriComplex®’, present in AnnurMets hair Shampoo, increases keratin production and hair thickness, bringing it health and body.

Composition
Water, Cocamidopropyl betaine, Ammonium lauryl sulfate, Lauryl glucoside, Sodium lauryl glucose carboxylate, Glycerin, Decyl glucoside, Xanthan gum, Glyceryl oleate, Argan oil polyglyceryl-6 esters, Coco-glucoside, Panthenol, Dicaprylyl ether, Macadamia ternifolia seed oil, Potassium sorbate, Quaternium-87, Sodium benzoate, Mel, Hydrolyzed keratin, Hydrolyzed wheat protein, Lactic acid, Aroma.

Detangling conditioner, from Melannurca Campana IGP ‘AnnurtriComplex’ extract, prevents hair dehydration after shampooing. The natural and light Melannurca formula is suitable for all types of textures, without weighing the hair down, it reinvigorates and helps the hair appearing stronger and healthier. It conveys shine, softness and combability to all hair types.

Composition
Water, Cetearyl alcohol, Cetrimonium Chloride, Algae, Malus Pumila Miller cultivar Annurca fruit extract AnnutriComplex, Potassium sorbate, Sodium benzoate, Bis- Cetearyl, amodimethicone, Ceteareth-25, Ceteareth-7, Pantheol, Caprylic/capric triglyceride, Maltodextrin, Royal jelly, Tetrasodium glutamate diacetate, BHA, BHT, Silica, Tocopheryl acetate, Aroma.

A protective restorative mask with Melannurca Campana IGP ‘AnnurtriComplex’ extract, that nourishes the hair in depth by giving it back softness and silkiness. Its natural Melannurca formula makes it suitable for all hair types. AnnurMets hair Mask is recommended for the treatment of damaged and dry hair fibre, by giving moisture and body and protecting against external aggression. It prevents rupture and split ends.

Composition
Water, Cetearyl alcohol, Dimethicone, Cetrimonium chloride, Glycerin, Quaternium-87, Behentrimonium chloride, Butyrospermum parkii butter, Polyquaternium-22, Argania spinosa oil, Babassu oil glycereth-8 esters, Almond oil glycereth-8 esters, Amodimethicone, Trideceth-12, Malus Pumila Miller cultivar Annurca Fruit exctract AnnurtriComplex, Bis-cetearyl-amodimethicone, ceteareth-25, ceteareth-7, Quaternium-91, Macadamia-termifolia-seed oil, Propylene Glycol, Urea, Cetrimonium methosulfate, Hydrolyzed keratin, Pantenol, Caprylic/Capric tryglicerid, Maltodextrin, BHA, BHT, Silica, Tocoferyl acetate, Aroma.

Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial. Gian Carlo Tenore, Carlo Irace, Ettore Novellino, et al. J Med Food 21 (1) 2018, 90–103; doi: 10.1089/jmf.2017.0016

Induction of Hair Keratins Expression by an Annurca Apple-Based Nutraceutical Formulation in Human Follicular Cells. Mariano Stornaiuolo , Gian Carlo Tenore , Carlo Irace, Ettore Novellino, et al. Nutrients 2019, 11, 3041; doi:10.3390/nu11123041

Annurca Apple Polyphenols Ignite Keratin Production in Hair Follicles by Inhibiting the Pentose Phosphate Pathway and Amino Acid Oxidation. Giancarlo Tenore, Pietro Campiglia, Mariano Stornaiuolo, Ettore Novellino, et al. Nutrients 2018, 10, 1406; doi:10.3390/nu10101406

Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation. Gian Carlo Tenore, Mariano Stornaiuolo, Ettore Novellino, et al. Nutrients 2018, 10, 1808; doi:10.3390/nu10111808

GC Tenore, D Caruso, G Buonomo, M D’Avino, R Santamaria, C Irace, M Piccolo, M Maisto, E Novellino. (2019). Response to Keith et al. Re: “Annurca Apple Nutraceutical Formulation Enhances Keratin Expression in a Human Model of Skin and Promotes Hair Growth and Tropism in a Randomized Clinical Trial”. Journal of Medicinal Food, 22(12):1303-1304, doi: 10.1089/jmf.2019.29003.gct.

Promelanogenic Effects by an Annurca Apple-Based Natural Formulation in Human Primary Melanocytes. Ferraro MG., Piccolo M., Pezzella A., Guerra F., Maione F., GC Tenore., Santamaria R, Irace C, Novellino E. Clinical, Cosmetic and Investigational Dermatology. 2021, 14 291–301.

Food supplement in tablet form with AnnurComplex®, an extract from Melannurca Campana IGP® and American potato, capable of modulating and limiting the absorption of cholesterol in the intestine and complementing its metabolism with a reduction in total and LDL cholesterolaemia values and a significant increase in HDL.
The efficacy of AnnurComplex® is proven by numerous clinical studies conducted in collaboration with the Department of Pharmacy of the University of Naples ‘Federico II’.

Composition
Melannurca (Malius pumila Miller cultivar Annurca) fruit Dry extract of procyanidin “AnnurComplex”, bulking agent: cellulose; anti-caking agents: magnesium salts of fatty acids, silicon dioxide and talc; yellow film coating: glazing agents: shellac, hydroxypropyl methylcellulose, talc, polyethylene glycol: colouring agents: calcium carbonate, iron oxides and hydroxides; potato American (Ipomea batatas L. Lamb.) tuber E.S;

Doses and usage information
S Recommended 2 capsules per day at main meals.
GLUTEN- AND LACTOSE-FREE
SUITABLE FOR VEGANS

Food supplement in tablet form with AnnurComplex® extract from Melannurca Campana IGP® and monacolin K from fermented red rice, that contributes to the maintenance of normal blood cholesterol levels by limiting its absorption in the intestine and enhancing its metabolism, with a reduction in total and LDL cholesterol levels and a significant increase in HDL. The addition of monacolin K maximises the cholesterolaemic-lowering effect.
The efficacy of AnnurComplex® is proven by clinical studies conducted in collaboration with the Department of Pharmacy of the University of Naples ‘Federico II’.

Composition
Melannurca (Malus pumila Miller cultivar Annurca) fruit dry extract procyanidin extract Annurcomplex®, red fermented rice from monascus purpureus; American potato (Ipomea batatas (L.) Poir. bulking agent: cellulose; anti-caking agents: magnesium salts of fatty acids, silicon dioxide and talc; red film (glazing agents: shellac, hydroxypropyl methylcellulose, talc, polyethylene glycol; colouring agents: iron oxides and hydroxides.

Doses and usage information
Recommended tablet per day, preferably in the evening.
GLUTEN- AND LACTOSE-FREE
SUITABLE FOR VEGANS

Tenore GC., Campiglia P., Stiuso P., Novellino E., et al. (2013). Nutraceutical potential of polyphenolic fractions from Annurca apple (M. pumila Miller cv Annurca). Food Chemistry. 15;140(4):614-22.

Tenore GC., Campiglia P., Novellino E., et al. (2013). In vitro bioaccessibility, bioavailability and plasma protein interaction of polyphenols from Annurca apple (M. pumila Miller cv Annurca). Food Chemistry. 141;4 3519-3524.

Tenore GC., Stiuso P., Novellino E., et al. (2014). Effects of Annurca apple polyphenols on lipid metabolism in HepG2 cell lines: A source of nutraceuticals potentially indicated for the metabolic syndrome. Food Research International. 63, 252-257.

Sommella E., Tenore GC., Novellino E., Campiglia P., et al. (2015). Detailed polyphenolic profiling of Annurca apple (M. pumila Miller cv Annurca) by a combination of RP-UHPLC and HILIC, both hyphenated to IT-TOF mass spectrometry. Food Research International. 76,3 466-477.

Tenore GC., Caruso D., Buonomo G., D’Urso E., D’Avino M., Campiglia P., Marinelli L., Novellino E. (2016). Annurca (Malus pumila Miller cv. Annurca) apple as a functional food for the contribution to a healthy balance of plasma cholesterol levels: results of a randomized clinical trial. J Sci Food Agric.

Tenore GC., Brancaccio D., Novellino E., et al. (2018). A nutraceutical formulation based on Annurca apple polyphenolic extract is effective on intestinal cholesterol absorption: A randomised, placebo-controlled, crossover study. PharmaNutrition, 6(3), 85-94.

Tenore GC., Caruso, D., D’Avino M., Novellino E., et al. (2017). A healthy balance of plasma cholesterol by a novel Annurca apple-based nutraceutical formulation: Results of a randomized trial. Journal of medicinal food, 20(3), 288-300.

Santini, A., & Novellino, E. (2017). Nutraceuticals in hypercholesterolaemia: an overview. British journal of pharmacology, 174(11), 1450-1463.

Sommella E., Badolati N., Riccio R., Salviati E., Bottone S., Dentice M, Campiglia,Tenore GC, Stornaiuolo M., Novellino E. (2018). A Boost in Mitochondrial Activity Underpins the Cholesterol-Lowering Effect of Annurca Apple Polyphenols on Hepatic Cells. Nutrients. 11, 163.

Tenore GC., D’Avino M., Caruso D., Buonomo G., Acampora C., Caruso G,, Simone C., Ciampaglia R., Novellino E. (2019). Effect of Annurca Apple Polyphenols on Intermittent Claudication in Patients With Peripheral Artery Disease. The American Journal of Cardiology. 1;123(5):847-853.

Badolati N., Masselli R., Maisto M., Di Minno A., Tenore G., Stornaiuolo M., Novellino E. (2020) Genotoxicity Assessment of Three Nutraceuticals Containing Natural Antioxidants Extracted from Agri-Food Waste Biomasses. Foods. 9, 1461.

Food supplement in tablet form with Taurisolo®, extracted from Aglianico wine pomaces, rich in catechins and resveratrol.
Fluxovas® has a specific protective action on the vascular system, enabling restoration of normal function, maintenance of vascular endothelial integrity and reduction of vascular obstruction. Studies conducted in collaboration with the Department of Pharmacy of the ‘Federico II’ University of Naples, the University of Pisa and the ‘Magna Græcia’ University of Catanzaro, have shown that Fluxovas®, is able to reduce the formation of pro-atherogenic metabolites that are prognostic of cardiovascular events, by minimising the circulating TMAO values.

Composition
Taurisol®, (Dry extract of the seeds and fruit pomace from Vitis Vinifera L.) bulking agent: cellulose; violet film (glazing agents: shellac, hydroxypropyl methylcellulose, talc, polyethylene glycol, acetic acid esters of mono- and glycerides of fatty acids and polyvinylpyrrolidone, colouring agents: calcium carbonate, cochineal, iron oxides and hydroxides, indigotine); anti-caking agents: magnesium salts of fatty acids, silicon dioxide and talc.

Doses and usage information
Recommended 1-2 tablets per day between meals.
GLUTEN- AND LACTOSE-FREE
SUITABLE FOR VEGANS

Food supplement in drops, with Taurisol® and AnnurComplex®.
Fluxogene, in its original formulation, exerts a vaso-protective action, strengthening the elasticity of the vessels and reducing leg swelling.
It is useful for the physiological function of the microcirculation in case of tired, heavy legs. In cases of marked venous insufficiency, it can be used in combination with one tablet/day of Fluxovas.

Composition
Purified water, Taurisol®, (Dry extract of the seeds and fruit pomace from Vitis Vinifera L.), Melannurca (Malus pumila Miller cultivar Annurca) fruit Annurcomplex® procyanidin dry extract, Horse chestnut mother tincture (Aesculus Hippocastanum L., seeds) Sweetener: Sucralose (E955). Preservatives: Potassium Sorbate, Sodium Benzoate. Aroma: Vanilla.

Doses and usage information
Recommended 25 drops (1.5 ml) once or twice a day, diluted in half a glass of water.
GLUTEN- AND LACTOSE-FREE
SUITABLE FOR DIABETICS
SUITABLE FOR VEGANS

100% Italian durum wheat semolina pasta, with the addition of Taurisolo®, an extract of Aglianico wine pomace rich in Resveratrol and Catechins.
Handcrafted, bronze-drawn and slowly dried at low temperatures.
Restoceutical product recommended for optimising cardiovascular function.

Composition
Ingredients: durum wheat semolina, water, pomace extract 4%.
May contain traces of soya.
Contains gluten.
Store in a cool, dry place.
Humidity 12.50 %.

Novellino E, Tenore GC, et al. (2019). Effects of Grape Pomace Polyphenolic Extract (Taurisolo®) in Reducing TMAO Serum Levels in Humans: Preliminary Results from a Randomized, Placebo-Controlled, Cross-Over Study. Nutrients, 10;11(1). pii: E139. doi: 10.3390/nu11010139.

Novellino E, Tenore GC, et al. (2019). Effect of Grape Pomace Polyphenols With or Without Pectin on TMAO Serum Levels Assessed by LC/MS-Based Assay: A Preliminary Clinical Study on Overweight/Obese Subjects. Front Pharmacol, 21;10:575. doi: 10.3389/fphar.2019.00575.

Novellino E, Stornaiuolo M, Tenore GC, et al. (2020). The Pomace Extract Taurisolo protects rat brain from ischemia-reperfusion injuries. Frontiers Cellular Neuroscience, 1,14,3, doi:10.3389/fncel.2020.00003

Annunziata G, Jimenez-García M, Tejada S, Moranta D, Arnone A, Ciampaglia R, Tenore GC, Sureda A, Novellino E, Capó X. (2020). Grape Polyphenols Ameliorate Muscle Decline Reducing Oxidative Stress and Oxidative Damage in Aged Rats. Nutrients, 12, 1280; doi:10.3390/nu12051280

Badolati N, Masselli R, Sommella E, Sagliocchi S, Di Minno A, Salviati E, Campiglia E, Dentice M, Tenore GC, Stornaiuolo M, Novellino E. (2020). The Hepatoprotective Effect of Taurisolo, a Nutraceutical Enriched in Resveratrol and Polyphenols, Involves Activation of Mitochondrial Metabolism in Mice Liver. Antioxidants, 9, 410; doi:10.3390/antiox9050410

Annunziata G, Solimeo A, De Angelis V, De Rosa P, Ciampaglia R, Guerra F, Maisto M, Tenore GC, Novellino E. (2021). Grape pomace polyphenols improve ophthalmic outcomes in patients with age-related macular degeneration (AMD) via reducing TMAO serum levels and oxidative stress: preliminary results from a pilot clinical trial. Pharmacologyonline, 2; 1479-1498.

Annunziata G, Capó X, Quetglas-Llabrés MM, Monserrat-Mesquida M, Tejada S, Tur J.A, Ciampaglia R, Guerra F, Maisto M, Tenore GC, Novellino E, Sureda A. (2021). Ex Vivo Study on the Antioxidant Activity of a Winemaking By-Product Polyphenolic Extract (Taurisolo®) on Human Neutrophils. Antioxidants, 10, 1009.
doi: 10.3390/antiox10071009

Annunziata G, Ciampaglia R, Maisto M, D’Avino M, Caruso D, Tenore GC, Novellino E. (2021). Taurisolo®, a Grape Pomace Polyphenol Nutraceutical Reducing the Levels of Serum Biomarkers Associated With Atherosclerosis. Frontiers in cardiovascular medicine, 7,8;697272 doi: 10.3389/fcvm.2021.697272

Badolati, Masselli R , Maisto M, Di Minno A, Tenore GC, Stornaiuolo M, Novellino E. (2020) Genotoxicity Assessment of Three Nutraceuticals Containing Natural Antioxidants Extracted from Agri-Food Waste Biomasses. Foods, 9, 1461, doi:10.3390/foods9101461

Lama S, Monda V, Rizzo MR, Dacrema, Maisto M, Annunziata G, Tenore GC, Novellino E, Stiuso P. (2020). Cardioprotective Effects of Taurisolo® in Cardiomyoblast H9c2 Cells under High-Glucose and Trimethylamine N-Oxide Treatment via De Novo Sphingolipid Synthesis. Oxidative Medicine and Cellular Longevity, 2961406, 11, doi:10.1155/2020/2961406

Martelli A, Flori L, Gorica E, Piragine E, Saviano A, Annunziata G, Di Minno M N D , Ciampaglia R, Calcaterra I , Maione F , Tenore GC, Novellino E, Calderone V. (2021) Vascular Effects of the Polyphenolic Nutraceutical Supplement Taurisolo®: Focus on the Protection of the Endothelial Function. Nutrients, 13, 1540, doi: 10.3390/nu13051540

The medical device VIRUVIN crema gel is a whole-natural topical formulation based on ‘Taurisolo®’ grape pomace extract, rich in polyphenols and resveratrol, used to prevent and reduce lip herpes discomfort. VIRUVIN cream gel creates a protective barrier on the lips that, in addition to its moisturising and soothing effect, prevents and reduces irritation caused by herpetic lip microdiffusion.

Composition
Water, Butyrospermum parkii butter, Cetearyl alcohol, Glyceryl stearate citrate, Vitis vinifera fruit (Taurisolo®) extract, Glycerin, Aloe barbadensis leaf juice, Potassium sorbate, Sodium benzoate, Oleyl alcohol, Zanthoxylum bungeanum fruit extract.

Usage information
Apply the cream gel on the affected area every two hours for 4 days. Best start the treatment as soon as possible, preferably at the onset of the symptomatic phase. In case of sun exposure, it is advisable to apply the product more frequently.

A food supplement in capsule form with micronised Chia seeds, Vitamin E and fenugreek to control triglyceride levels in the blood.
The efficacy of TrigoNorm is proven by clinical studies conducted by the Department of Pharmacy of the University of Naples ‘Federico II’.

Composition
Chia seed (Salvia Hispanica) micronised powder, hydroxypropylmethylcellulose and gellan gum capsule; Vitamin E powder 50% (DL-alpha-tocopheryl acetate); Fenugreek (Trigonella foenum graecum L.) seed i.e., E:D 1:4; anti-caking agent: magnesium salts of fatty acids.

Doses and usage information
2 capsules per day, at main meals.

Gian Carlo Tenore, Domenico Caruso, Giuseppe Buonomo, Maria D’Avino, Roberto Ciampaglia, Ettore Novellino. Plasma lipid lowering effect by a novel chia seed based nutraceutical formulation. Journal of Functional Foods 42 2018 38–46

Elisabetta Schiano, Annunziata Giuseppe, Ciampaglia Roberto, Fortuna Iannuzzo, Maria Maisto, Gian Carlo Tenore, Ettore Novellino. Bioactive Compounds for the Management of Hypertriglyceridemia: Evidence From Clinical Trials and Putative Action Targets. Frontiers in Nutritions 2020 7-586178.

Delezen Cream is a medical device based on natural extracts with soothing and cooling properties for topical use on uninjured skin. It counters muscle tension by relieving pain and is useful in the presence of joint pain. It performs its action thanks to the composition of a lipid microfilm that promotes effective local activity. It is irecommended in case of muscle tension, sprains, contusions, strains, tendonitis, rheumatism, arthritis, sinus headache. Also ideal to facilitate massaging after physical activity, muscle cramps and contractures.
Its formula is inspired by Chinese popular medicine and exploits the combined action of powerful soothing principles with known natural anti-inflammatory properties.
Characterised by a delicate, fragrant odour, it promotes blood circulation and muscle detumescence. Applied to the skin, it is quickly absorbed and gives an immediate sensation of freshness that relieves muscle tension and helps reducing muscle and joint pain.

Composition
Butyrospermum parkii butter, Theobroma cacao seed butter, Menthol, Methyl salicylate, Cera alba, Mangifera indica seed butter, Alcohol denat, Camphor, Eucalyptus globulus leaf oil, Mentha piperita oil, Cellulose, Resveratrol, Rosmarinus officinalis leaf oil, Aqua, Alcohol, Palmitic/stearic triglyceride, Cymbopogon nardus oil, Berberis vulgaris, Rheum palmatum, d-Limonene, Geraniol, Citronellol, Linalool, Farnesol.

Usage information
Apply small amounts of Delezen Cream 2 to 4 times a day as needed, massaging in until absorbed.